Painful and Painless Diabetic Neuropathies: What Is the Difference?

Clinical management of the painful diabetic neuropathies.

340 Journal of the Royal College of Physicians of London Vol. 34 No. 4 July/August 2000 The neuropathies of diabetes are common, affecting up to 50% of older patients with type 2 diabetes. They have been the subject of several recent reviews1–3. Only a minority of patients experience neuropathic symptoms, so the absence of symptoms must never be equated with the absence of neuropathy1–3. A care...

Obesity and diabetic retinopathy: What is the association?

Painful Diabetic Neuropathy Is Associated With Greater Autonomic Dysfunction Than Painless Diabetic Neuropathy

OBJECTIVE Although a clear link between diabetic peripheral neuropathy (DPN) and autonomic neuropathy is recognized, the relationship of autonomic neuropathy with subtypes of DPN is less clear. This study aimed to investigate the relationship of autonomic neuropathy with painless and painful DPN. RESEARCH DESIGN AND METHODS Eighty subjects (20 healthy volunteers, 20 with no DPN, 20 with painf...

Painful and painless channelopathies.

The discovery of genetic variants that substantially alter an individual's perception of pain has led to a step-change in our understanding of molecular events underlying the detection and transmission of noxious stimuli by the peripheral nervous system. For example, the voltage-gated sodium ion channel Nav1.7 is expressed selectively in sensory and autonomic neurons; inactivating mutations in ...

Painful neuropathies.

PURPOSE OF REVIEW To summarize the current understanding of clinical assessment, pathophysiology, and treatment of pain in neuropathies, focusing on selected entities in which the understanding of the mechanisms underlying pain has advanced recently. RECENT FINDINGS Ongoing studies are classifying the symptoms and signs of painful neuropathies, assuming that this approach may indicate particu...